Attempts have been made to study two presuppositions dominating any scientific research as the most radical points in interaction between religion and science and support of religion for modern science, i.e. the possibility of cognition and rationality of considering the world as a lawful and orderly entity and that man’s cognitive senses are reliable and he can achieve cognition of the world. Also it will be demonstrated that during the course of development of science, Abrahamic religions have been able to explain these two presuppositions in theory and practice and establish them in the unconsciousness of scientists and scholars. Moreover, it will be demonstrated that metaphysical naturism is unable to give an appropriate explanation of these two presuppositions.