The existing research demonstrates that one of the most important predictors of divorce in Iranian society is interference of families of spouses in the couples’ affairs. The present prepare is an attempt to study the role of quality of spouses’ relationships with their main families in predicting their marital satisfaction. 109 available married women and 63 married men were selected. The instruments used included Enrich Marital Satisfaction Assessment instrument as well as a questionnaire for assessing the relations with the main families. The data were analyzed by employing Pearson’s correlation and stepwise regression analysis. The findings of the paper demonstrate that the variable of couples’ satisfaction with relations with the two families accounts for 40% of variation in marital satisfaction; 35% of variation in the couples’ relations, 28% of variation in conflict resolution and 32% of variations in ideal falsification. The results of the research also show that creation of connection between couples and main families plays an important role in marital satisfaction in Iranian society. The authors suggested specific preventive and curative interventions for promotion of couples’ relations with the main families.